Aaron Jones rushed for a career-high 131 yards and a touchdown against the Saints on Sunday, but it wasn't enough as New Orleans beat Green Bay by a final of 26-17.
Jones ran for 125 yards two weeks ago in a win over Dallas - a mark that stood as his previous high.
The former UTEP running back also set a new mark for the longest single run of his career when he broke free for a 46-yard touchdown in the first quarter.
Jones recorded his 131 yards on only 17 carries, averaging nearly eight yards per attempt.
He also added three catches for a total of seven yards.
UTEP's all-time leading rusher has now carried the ball at least 13 times in each of the last four games for Green Bay.
The Packers fell to 4-3 with the loss while the Saints improved their record to 4-2.