Former President Bill Clinton weighed in one of the election's pressing international issues Tuesday saying Iran's President Mahmoud Ahmadinejad cannot be trusted regarding his country's nuclear ambitions.

In an interview on CNN's "Piers Morgan Tonight" to air Tuesday at 9 pm E.T., Clinton also addressed domestic politics and the strike by the NFL referees. Regarding Republican nominee Mitt Romney's potentially damaging "47%" comments, Clinton forecast that continuing to defend the remarks will be detrimental to the former governor in the election. And his ruling on the questionable, game-changing call made by a replacement referee on Monday night's prime time football game mirrored that of many observers.

Asked to respond to the Iranian president questioning why his country cannot have nuclear weapons if other countries can, Clinton, in turn, posed a rhetorical question:

"Why isn't [Ahmandinejad] going for some bigger non-proliferation initiative instead of acting like what he really wants is a nuclear bomb because that will help to get everybody get rid of their nuclear weapons?"

"No serious person believes that," Clinton answered in the interview.

Iran's nuclear program has been a hot issue on the international stage and has proved a significant talking point for candidates' in this year's election. Romney has charged President Barack Obama with a lack of seriousness and consideration for the United States' ally Israel which views Iran's development of nuclear weapons as an existential threat.

The Obama administration has pushed back on their opponent's characterization, maintaining that the U.S.-Israel relationship remains strong.

Responding to a joke made by Romney earlier Tuesday at the Clinton Global Initiative in New York saying "If there's one thing we've learned, a few words from Bill Clinton can do someone a lot of good.." Clinton simply reiterated his prediction that Romney faces a burden in the coming debates.

"I think if he's going to double down on that 47% remark, that will cause difficulties, because we now know the overwhelming number of those people work and have children, and the reason they don't pay federal income taxes is that median income is as low as it was in 1995 now," said Clinton.

Romney made the controversial "47%" comments in a secretly recorded video that surfaced earlier this month and was posted to a liberal-leaning magazine website. The video shows Romney courting wealthy donors at a private fund-raiser in Florida speaking candidly about what he claims are nearly half of Americans who will automatically vote for the president because they are dependent on government, among other contentious remarks that sparked sharp criticism.

And on the Monday Night Football fiasco over a questionable call made by a replacement referee ultimately handing the game to the Seattle Seahawks over the Green Bay Packers Clinton said it was a bad call and Seattle should not have been awarded a touchdown.

"I thought the pass was intercepted," said Clinton of the play by Seahawks wide receiver Golden Tate deemed a touchdown though it seemed to many that the Packers defender M.D. Jennings intercepted the ball.

"I thought the defender hit the ground before there was joint possession. And, yes, it means that we need to get the strike over and get more experienced people in there."

Watch CNN's Piers Morgan's full interview with Bill Clinton at 9 pm E.T. on "Piers Morgan Tonight"